What do we see in today's readings? After the Resurrection, the apostles worked "many signs and wonders...among the people" (Acts 5:12). "(T)he sick and those disturbed by unclean spirits...were all cured." (Acts 5:16) They received visions (Rev 1:10-11) and sacramental power by the Holy Spirit (John 20:22-23). They were in the company of the glorified Christ (Rev 1:17-18, John 20:19).
We also see doubt (John 20:25) and persecution (Rev 1:9). The Church was born from the pierced side of Christ, and two thousand years has not dulled the spear thrusts that come from the rest of the world. Doubt and persecution persist to this day.
What do we do? We believe in Christ. We hope in Christ. "Jesus is the Christ, the Son of God... through this belief you may have life in his name." (John 20:31) What persecution matters compared to that?
What doubts or persecutions do you face today? Bring them to Jesus in prayer. Better yet, bring them to Him in person.